好词典

oncogenes

UK //ˈɒŋkəʊdʒiːnz//US //ˈɑːŋkoʊdʒiːnz//

词源

源自希腊语 'onkos'(肿块) + 'gene'(基因),1969年由Robert Huebner和George Todaro首次提出。

noun

❶ 致癌基因,指某些在细胞中正常存在的基因,当发生突变或被异常激活时,可能导致细胞癌变并促进肿瘤生长。

“Scientists have identified several oncogenes that contribute to the development of breast cancer.”

(科学家已鉴定出多个与乳腺癌发展相关的致癌基因。)

“The activation of oncogenes can transform normal cells into cancerous ones.”

(致癌基因的激活可将正常细胞转化为癌细胞。)

同义词:cancer-causing genes, tumorigenic genes, proto-oncogenes (when referring to their normal, non-mutated form)

常见短语

oncogene activation — 致癌基因激活,指原本正常的基因因突变或表达异常获得促癌能力的过程。

“Oncogene activation is a critical step in the formation of many cancers.”

(致癌基因激活是许多癌症形成的关键步骤。)

oncogene addiction — 癌基因依赖,描述某些癌细胞高度依赖特定致癌基因维持其恶性特征的现象。

“Targeted therapies exploit oncogene addiction to selectively kill cancer cells.”

(靶向治疗利用癌基因依赖特性选择性杀死癌细胞。)